Outcomes of Other Medication on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (important route) and CYP2C9 (slight route). Therefore, inhibitors of those isoenzymes may lessen sildenafil clearance and inducers of those isoenzymes may boost sildenafil clearance.Furthermore, N-desmethyl metabolite AUC and Cmax values significantly en